Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) are two commonly prescribed classes of antidepressants, each working uniquely to alleviate symptoms of depression and anxiety.

Mechanisms of Action

• SSRIs function by increasing serotonin levels in the brain. Serotonin is a neurotransmitter that contributes to feelings of well-being and happiness. By blocking the reabsorption (reuptake) of serotonin into neurons, SSRIs enhance its availability in the synaptic space, thereby improving mood regulation.

• SNRIs, on the other hand, target both serotonin and norepinephrine. Norepinephrine is another neurotransmitter involved in regulating mood, alertness, and energy. By inhibiting the reuptake of both neurotransmitters, SNRIs can be particularly effective for individuals experiencing low energy levels or chronic pain in addition to depression.

Conditions Treated

Both SSRIs and SNRIs are primarily used to treat major depressive disorder and various anxiety disorders. Additionally, SNRIs may be prescribed for conditions such as fibromyalgia and neuropathic pain due to their influence on norepinephrine pathways.

Side Effect Profiles

While both medication classes are generally well-tolerated, they can have different side effect profiles:

• SSRIs: Common side effects may include nausea, insomnia, dizziness, weight changes, and sexual dysfunction.

• SNRIs: In addition to similar side effects as SSRIs, SNRIs may also cause increased blood pressure, dry mouth, and excessive sweating. Regular monitoring is essential to manage these potential effects.

Choosing the Right Medication

Selecting between an SSRI and an SNRI depends on individual symptoms, medical history, and how one responds to treatment. A thorough evaluation with a healthcare professional is crucial to determine the most appropriate medication tailored to one's specific needs.

If you're considering antidepressant options or seeking support for mental health concerns, professional guidance can make a significant difference. We invite you to schedule a free discovery call with Dr. Doi to explore personalized strategies for your well-being.