Tricyclic antidepressants (TCAs) are a class of medications primarily used to treat major depressive disorder. They function by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine, thereby modulating mood, attention, and pain.

Common TCAs include:

• Amitriptyline

• Nortriptyline (Pamelor)

• Imipramine (Tofranil)

• Clomipramine (Anafranil)

• Doxepin (Silenor)

• Desipramine (Norpramin)

While TCAs can be effective, they often cause more side effects than newer antidepressants. As a result, they are generally not prescribed unless other antidepressants have been tried first without improvement.

In addition to depression, TCAs are used to treat various conditions, including anxiety disorders, chronic nerve-related pain, migraine prevention, obsessive-compulsive disorder, panic attacks, and post-traumatic stress disorder (PTSD).

Common side effects of TCAs may include dry mouth, blurred vision, constipation, urinary retention, and drowsiness. It's important to discuss these potential side effects with your healthcare provider to determine the most appropriate treatment plan for your individual needs.

If you're considering treatment options for depression or other mental health concerns, we invite you to schedule a free discovery call with Dr. Doi. Together, you can explore the best path forward for your mental health and well-being.